病毒感染激活炎症小体的分子机制

doi:10.11843/j.issn.0366-6964.2016.11.003

Abstract

Abstract:

Inflammasomes are multiprotein complexes that induce downstream immune responses to environmental stimuli, specific pathogens and host cell damage, leading to the pyroptotic cell death of host cells. Inflammasomes mainly consist of recognition receptors of inflammatory signals ASC (the adapter apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain) and pro-caspase-1. Once activated, inflammasomes can induce the activation of caspase-1 and maturation of inflammatory cytokines, including IL-1β and IL-18. Inflammasomes can be classed into the NLR (nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3) inflammasome and the ALR (absent in melanoma 2 like receptor) inflammasome on the basis of the types of inflammatory signals recognition receptors. Host cells can recognize different viral components, including viroporins, non-structural proteins, viral double-stranded DNA and viral single stranded RNA, by different inflammatory signals recognition receptors and promote the formation of responding inflammasomes. Herein, we outlined the mechanisms of inflammasome formation activated by diverse viral components, and therefore provide a reference for future research and development of novel antiviral drugs.

CLC Number:

S852.4

GAO Ze-qian, ZHU Xue-liang, ZHANG Zhi-dong, DOU Yong-xi. The Mechanisms of Inflammasomes Activation by Viral Components[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(11): 2167-2174.

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The Mechanisms of Inflammasomes Activation by Viral Components

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